vitamin d modulates the expression of il-27 and il-33 in the central nervous system in experimental autoimmune encephalomyelitis

Authors

marziyeh mohammadi-kordkhayli

neuroscience research center, institute of neuropharmacology rayhane ahangar-parvin

department of immunology, medical school, rafsanjan university of medical sciences, rafsanjan sayed vahab azizi

department of immunology, medical school, rafsanjan university of medical sciences, rafsanjan maryam nemati

department of immunology, medical school, kerman university of medical sciences, kerman ali shamsizadeh

abstract

background: it has been reported that vitamin d has broad anti-inflammatory and immunomodulatory effects. objective: to evaluate the effects of vitamin d on the expression of il-27 and il-33 in a model of experimental autoimmune encephalomyelitis (eae). methods: eae was induced in c57bl/6 mice by immunization with myelin oligodendroglial glycoprotein mixed with complete freund's adjuvant. the mice were administered with pbs or olive oil, intraperitoneally, in the control groups and vitamin d (200 ng every two days) in the treatment group, from day +3 to +30. at day 31, the mice were scarified and their spinal cords and brains were harvested. the expression of the il-27 and il-33 mrna in the spinal cord was measured using real time-pcr. results: in pbs- or olive oil-treated eae mice the expression of il-27 p28 mrna was significantly lower than that in the healthy control group (p

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Journal title:
iranian journal of immunology

جلد ۱۲، شماره ۱، صفحات ۳۵-۴۹

Keywords
[ ' e x p e r i m e n t a l a u t o i m m u n e e n c e p h a l o m y e l i t i s ' , ' i l ' , 2 7 , ' i l ' , 3 3 , ' v i t a m i n d ' ]

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