vitamin d modulates the expression of il-27 and il-33 in the central nervous system in experimental autoimmune encephalomyelitis
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abstract
background: it has been reported that vitamin d has broad anti-inflammatory and immunomodulatory effects. objective: to evaluate the effects of vitamin d on the expression of il-27 and il-33 in a model of experimental autoimmune encephalomyelitis (eae). methods: eae was induced in c57bl/6 mice by immunization with myelin oligodendroglial glycoprotein mixed with complete freund's adjuvant. the mice were administered with pbs or olive oil, intraperitoneally, in the control groups and vitamin d (200 ng every two days) in the treatment group, from day +3 to +30. at day 31, the mice were scarified and their spinal cords and brains were harvested. the expression of the il-27 and il-33 mrna in the spinal cord was measured using real time-pcr. results: in pbs- or olive oil-treated eae mice the expression of il-27 p28 mrna was significantly lower than that in the healthy control group (p
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Journal title:
iranian journal of immunologyجلد ۱۲، شماره ۱، صفحات ۳۵-۴۹
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